Evaluation of cytoprotective impact of Asiatic acid during hyperglycemia in Hep G2 Cell line

Abstract

Plant metabolites are promising sources for the development of safe hypoglycemic drugs mainly due to their enhanced compatibility in biological systems. The present study was designed to investigate the antidiabetic activity of a plant derived triterpene; Asiatic acid obtained from the derived from Centella asiatica. In vitro results showed that Asiatic acid exhibited the potential to reverse the cytotoxic manifestations caused by hyperglycemia and significantly increased extracellular glucose consumption in HepG2 cells. We have demonstrated that Asiatic acid brings all diabetic parameters including GSH level and expression of different caspases to the comparable level of untreated group. Our results signify the antidiabetic potential of Asiatic acid and provide evidence to support the application of the substance in the treatment of diabetes.