Familial multiple cutaneous leiomyomatosis in siblings: A rare case report

Abstract

Piloleiomyoma, also known as Leiomyoma cutis, is a rare and benign smooth muscle tumour developing from the arrector pili muscle. It typically manifests as reddish-brown papules or nodules that are commonly present over the trunk and extremities, and are frequently associated with episodic pain. Familial multiple cutaneous leiomyomatosis have been reported in twins, siblings and multiple generations in a family which have a genetic predisposition and are found to be closely associated with uterine leiomyomas and renal cell carcinomas. In this article, we report a rare case of multiple cutaneous leiomyomatosis in siblings aged 54 years and 58 years respectively, diagnosed clinically and further confirmed with histopathological examination revealing typical features of cutaneous leiomyoma and positive immuno-histochemical testing for smooth muscle actin (SMA).