Study on the formulation of transdermal patches of zolpidem tartrate therapy

Abstract

Getting a controlled and sustained dose of Zolpidem tartrate therapy for the treatment of anxiety disorders was the purpose of the current study. The technique of film casting was utilised in the preparation of the matrix type of transdermal drug delivery. In order to characterise and evaluate the formulations, various parameters such as in vitro drug release and skin permeation studies were conducted. The effect of varying ratios of matrix-forming polymer, specifically Eudragit RL 100 and Eudragit RS100, combined with PVP K 30 was investigated in terms of its influence on in vitro drug release. According to the findings, the percentage of cumulative drug release after 48 hours for each of the different formulations ranged anywhere from 66 to 81 percent. The values that corresponded to the cumulative amount of drug permeation ranged anywhere from sixty to eighty percent. This innovative method of administering the drug via the skin results in a greater amount of the drug's effects being maintained over time.