Mixed ligand complexes of nickel (ii): Synthesis and bio medicinal studies

Abstract

Mixed ligand nickel (II), complexes of 2, 2 bipridyle and thioamides of 2-aminopyridine, 2-aminoadinine, 2-aminoguanine and 2-aminocytocine were prepared. The success of synthesis was confirmed through physical and spectral characterization on the basis of IR and NMR spectroscopy, antimicrobial and antitumour studies. The synthesized compounds were found to be active against the tested three bacterial strains (Pseudomanas auruginosa, Klebseila pneumonia and Staphylococcus aureus), two fungal strains (Aspergillus flavus and Aspergillus nigar) and antitumour activity against MCF-7 (Human breast adenocarcinoma) cell line.