Nephrology protective activity of polysaccharide from red macroalga Falkenbergia rufolanosa against methyl Thiophanate-induced oxidative stress and kidney inflammation

Abstract

This study sought to investigate the protective potentials conferred by the polysaccharide extracted from red marine alga Falkenbergia rufolanosa (FRP) against methyl Thiophanate (MT)-induced oxidative injuries in kidney tissue. Therefore, adult wistar rats were divided in four groups: control; MT (700 mg/kg) injected intraperitoneally for 3 days; FRP (200 mg/kg) administrated via alimentation for 7 days followed by MT co-injection at the last 3 days and only FRP (200 mg/kg) administrated via alimentation for 7 days. Data revealed a significant perturbation in plasma biochemical and oxidative stress parameters associated with the Nephrology toxicity features. These results were confirmed by kidney his to-architecture consorted by detection of Bcl-2, IL-1beta, and P53 examined via immunohistochemistry revelation. Nevertheless, co-treatment with FRP regulated MT-induced Nephrology toxicity as shown by an improvement in kidney biochemical, histological and immunohistochemistry profiles. In conclusion, FRP could be considered as a good source of naturally occurring antioxidant and Nephrology protective agent.