Transient abnormal myelopoiesis at birth with Down syndrome: A rare case report

Abstract

Down syndrome is associated with rare hematological disorder like Transient abnormal myelopoiesis in infants. We report a case of preterm female baby with low birth weight born to 33 year old mother who is G2A1 at 34 weeks of gestation. Antenatal checkup revealed intermediate risk for Down syndrome. On the first day of birth CBC showed high WBC count of127000/ mm3 and peripheral smear showed 13% of blast and the total count gradually decreased to normal of 20000/ mm3 over a period of one month. The baby succumbed to death due to Congestive cardiac failure and late onset sepsis.