Development of hyperimmune serum for diagnosis and therapy against Jembrana disease in Bali cattle

Abstract

Bali cattle are indigenous Bali that has been widely distributed throughout Indonesia, form about 27% of the total cattle population, and they make the highest contribution to beef production in Indonesia. The animals possess many superiorities compared to other breeds but they are very susceptible to Jembrana disease virus (JDV) infection which is classified as one of the strategic-infectious animal diseases. The purpose of this study was to provide hyperimmune serum appropriate for the treatment of JDV infection and routinely serological diagnosis. The hyperimmune serum against JDV infection was provided using the method of Mhoma method and hyperimmune was developed using a different types of vaccines. firstly immunized intramuscularly with vaccine containing the CFA adjuvants and the second were prepare with the commercial vaccine twice at one monthly interval. Prophylaxis with these hyperimmune after infection was failed in challenge experiments.