Cinnamons effect on apoptosis, inflammation and trpm2 channels in methotrexate induced renal damage

Abstract

Introduction: In this study, it was aimed to investigate the potential protective effects of cinnamon (CIN) against methotrexate (MTX) induced kidney damage.Materials and Methods: Spraque dawley male rats were divided into five groups (n = 7) as: control group received no treatment; oil group was administered 1ml/kg olive oil (OO) by oral gavage during the experiment; MTX group was given OO by gavage once a day for 14 days and a single dose of 20 mg/kg MTX was injected intraperitoneally on the third day; CIN group was given 100 mg/kg CO (CIN bark oil) by oral gavage throughout the experiment; MTX+CO group received 100 mg/kg CO throughout the experiment and injected with a single dose of 20mg/kg MTX IP on the third day. In the end of the experiment, the animals were decapitated and the kidneys were removed.Results: MTX administration caused glomerular atrophy, tubular enlargement and increased TRPM2 immunoreactivity on kidney tissue and CIN reversed these changes significantly.Conclusion: In this study, it was determined that MTX caused histological damage on kidney tissue and CIN reduced this damage.