To study the safety of aqueous extract of Emblica officinalis on biochemical markers of liver and kidney function and oxidative stress indices in albino rats

Abstract

The present study was performed in three groups of rats, consisting six rats in each group. The rats of group I were served as control. However, VI and VII were treated with aqueous extract of Emblica officinalis @ 200 mg/kg b. wt. and aqueous extract of Emblica officinalis @ 400 mg/kg b. wt., respectively. All the groups received medication orally, once daily for 28 days. Emblica officinalis did not alter the concentration of biochemical markers of liver function viz. ALT, AST, GGT, ALP, albumin and bilirubin as compared to control treated group. The concentration of biochemical markers of kidney function viz. BUN and creatinine was not alter after the administration of aqueous extract of Emblica officinalis as compared to control group. The safety profile of aqueous extract of Emblica officinalis was evaluated. The results of the present study indicated that the aqueous extract of Emblica officinalis @ 200 mg/kg b. wt. and 400 mg/kg b. wt. orally for 28 days did not alter the oxidative stress indices and biochemical markers of liver and kidney function as compared to control.