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Metal–Organic Frameworks as Efficient Materials for Drug Delivery

Angewandte Chemie · 2006 · Vol. 118(36) · pp. 6120–6124
Patricia HorcajadaChristian SerreMaría Vallet‐RegíMuriel SebbanFrançis TaulelleGérard Férey

Abstract

Pack sie voll: Die Metallcarboxylate MIL-100 und MIL-101 fungieren als poröse Matrices (siehe Bild) in Wirkstofftransportsystemen mit Ibuprofen als Modellsubstrat. Sie konnten sehr große Mengen Wirkstoff aufnehmen (bis zu bisher unerreichten 1.4 g Wirkstoff pro Gramm MIL-101), und Ibuprofen wurde unter physiologischen Bedingungen in 3 (MIL-100) bzw. 6 Tagen (MIL-101) vollständig freigesetzt. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z601878_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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