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Matrix Metalloproteinases

Journal of Biological Chemistry · 1999 · Vol. 274(31) · pp. 21491–21494

Hideaki Nagase✉(University of Kansas Medical Center)J. Frederick Woessner(University of Miami)

Abstract

The timely breakdown of extracellular matrix (ECM)1 is essential for embryonic development, morphogenesis, reproduction, and tissue resorption and remodeling. The matrix metalloproteinases (MMPs), also called matrixins, are thought to play a central role in these processes. The expression of most matrixins is transcriptionally regulated by growth factors, hormones, cytokines, and cellular transformation (1, 2). The proteolytic activities of MMPs are precisely controlled during activation from their precursors and inhibition by endogenous inhibitors, α-macroglobulins, and tissue inhibitors of metalloproteinases (TIMPs).

Protease and Inhibitor Mechanisms Blood Coagulation and Thrombosis Mechanisms Macrophage Migration Inhibitory FactorMatrix metalloproteinaseExtracellular matrixCell biologyBiologyPlasminogen activatorMolecular biologyBiochemistryEndocrinology

MeSH terms

AnimalsExtracellular MatrixMetalloendopeptidasesModels, MolecularVertebratesGene Expression Regulation, EnzymologicProtein Structure, SecondaryMatrix Metalloproteinase 3Tissue Inhibitor of MetalloproteinasesTissue Inhibitor of Metalloproteinase-1

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