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International Journal of Applied Research · 2020 · Vol. 6(6)
Vijayendra Gautam✉(Gajara Raja Medical College)Devendra S Doneriya(Gajara Raja Medical College)K KroenkeP VerhaakJ KerssensJ DekkerM SorbiJ BensingR SternbachJean-Philippe VitT PeterAditi OharaKanwar BhargavaLuc KelleyJasminF BelardettiG ZamponiW CatterallS Dib-HajjM MeislerD PietrobonG ZamponiR LewisS TodorovicS ArnericT SnutchT YakshJ McgivernS McdonoughE BourinetG ZamponiC SchroederC DoeringG ZamponiR LewisC SiauG BennettV JainA JaggiN SinghR NeckerR HellonE MatthewElizabeth BartonHarlan EberleS TodorovicV Jevtovic-TodorovicA MeyenburgS MennerickE Perez-ReyesC RomanoA DorulL GardellM OssipovF TulunayJ LaiF PorrecaJ SarahFlatters GaryJG HamidiM RamezaniM AraniS TalaeiA MesdaghiniaH Banafshe
Abstract
Background: Neuropathic Pain is recognized as one of the most difficult type of pain to treat with conventional analgesics. Several evidence implicate that T-type VGCC in Pathophysiology of neuropathic and inflammatory pain. Ethosuximide, a T type VGCC blocker thus can be useful in Neuropathic Pain. Objectives 1. To evaluate the analgesic activity of Ethosuximide in Normal rats. 2. To evaluate the analgesic activity of Ethosuximide in Vincristine induced animal model of neuropathic Rats. Material & Methods Drugs: Ethosuximide, Vincristine.
Environmental science
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