Effect of repeated oral administration of Butachlor on oxidative stress parameters and histopathological changes in wistar rats

Abstract

The experiment was conducted with wistar rats divided into two groups for a period of 28 days and was given through oral gavage. Group I served as control and was provided with water only for drinking purposes. Animals of Group II Animals of group 2 were administered Butachlor (Mancheter EC) @262 mg/kg B.W/P.O. Increase in lipid peroxidation and decrease in blood glutathione, glutathione peroxidase and transferase, catalase and superoxide dismutase in blood and tissues respectively revealed a clear picture of oxidative stress. Histopathologically, liver and kidney exhibited structural alterations as compared to control.