A comparative study of low molecular weight heparin in the management of acute pancreatitis VS conventional treatment- a prospective comparitive clinical study

Abstract

Acute pancreatitis is serious disorder in any kind of severity with a mortality up to 20-40% and with a high magnitude of morbidity due to other kinds of systemic complications and despite of the various aetiologies, the final outcome is premature activation and retention of proteolytic enzymes. The main triggering factor and the etiological factor in development of Severe Acute Pancreatitis leading to multiple organ failure is the disturbance in microcirculation of the pancreas. The standard treatment for pancreatitis that is given is fluid management, nutritional care, gastrointestinal decompression, antibiotics (when indicated) The need for introducing Low molecular weight heparin (LMWH) in the treatment line of acute pancreatitis is that LMWH can reduce the release of cytokines and inflammatory mediators, resulting in an improvement of the microcirculation of pancreas thereby minimising the severity of pancreatic necrosis.