The effect of periodontal therapy on glycaemic level in patients with controlled type 2 diabetes mellitus on sulfonylurea oral hypoglycaemic agents

Abstract

Background: This study was aimed at evaluating the relationship between glycaemic level and inflammatory status of periodontium following a thorough non-surgical periodontal therapy in type 2 diabetic patients on sulfonylurea group of hypoglycaemic agents. Methods: 28 chronic periodontitis patients having controlled type 2 diabetes (HbA1c ≤ 8%) on sulfonylureas were selected for the study. The gingival inflammatory status was evaluated by estimating aspartate aminotransferase in gingival crevicular fluid (GCF-AST) and gingival index (GI). The glycaemic condition was assessed using fasting blood sugar level (FBS). The FBS, GI and GCF-AST levels were assessed prior to periodontal therapy, after 24 hours, 7th day, 14th day and 3rd month of treatment. Results: The study demonstrated a strong co-relation between the gingival inflammatory status and the glycaemic level of patients following periodontal therapy. Both GI and GCF-AST was found consistent with FBS under the study conditions. Statistically significant reduction (p