To compare the effect of intraperitoneal instillation of ropivacaine 0.75% 10ml, and ropivacaine with dexmedetomidine 1mcg/kg for post-operative analgesia after laparoscopic cholecystectomy

Abstract

Background: To compare the effect of intraperitoneal instillation of ropivacaine 0.75% 10 ml, and ropivacaine with dexmedetomidine 1mcg/kg for post-operative analgesia after laparoscopic cholecystectomyMaterials and Methods: This is a prospective, randomised study conducted out on 100 patients of either sex, aged 18-60 years, ASA grade I and II scheduled for laparoscopic cholecystectomy.Results: Intra-peritoneal instillation of 0.75%ropivacaine with dexmedetomidine provides superior and prolonged pain relief without any adverse effects, making its use simple, safe and effective for postoperative analgesia in laparoscopic cholecystectomy. All the results were significant statistically and have correlated well with the studies in reference.Conclusion: we concluded that dexmedetomidine 1µg/kg can be used as adjuvant to 0.75% ropivacaine for effective post-operative analgesia in laparoscopic cholecystectomy. Intra-peritoneal instillation of 0.75%ropivacaine with dexmedetomidine provides superior and prolonged pain relief without any adverse effects, making its use simple, safe and effective for postoperative analgesia in laparoscopic cholecystectomy. Hence, we concluded that use of dexmedetomidine as additive to ropivacaine for intra-peritoneal instillation and port site infiltration in patients posted for elective laparoscopic cholecystectomy, as it significantly prolongs duration of analgesia along with minimal side effects as compared to infiltration with ropivacaine alone.