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Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡

Human Reproduction · 2018 · Vol. 33(9) · pp. 1602–1618
Helena TeedeMarie MissoMichael CostelloAnuja DokrasJoop S.E. LavenLisa MoranTerhi PiltonenRobert J. NormanInternational PCOS NetworkMarianne AndersenRicardo AzzizAdam BalenEstifanos BayeJacqueline BoyleLeah BrennanFrank J. BroekmansPreeti DabadghaoLuigi DevotoDidier DewaillyLinda DownesBart C.J.M. FauserStephen FranksRhonda GaradMelanie Gibson‐HelmCheryce L. HarrisonRoger HartRachel HawkesAngelica Lindén HirschbergKathleen M. HoegerFemke HohmannSamantha K. HutchisonAnju E. JohamLouise JohnsonCailin JordanJayashri KulkarniRichard S. LegroRong LiMarla E. LujanJaideep MalhotraDarren MansfieldKate MarshVeryan McAllisterEdgar MocanuBen W. MolErnest Hung Yu NgSharon E. OberfieldSasha OtteyAlexia PeñaJie QiaoLeanne M. RedmanRaymond J. RodgersLuk RombautsDaniela RomualdiDuru ShahJane SpeightPoli Mara SpritzerElisabet Stener‐VictorinNigel K. SteptoJuha S. TapanainenEliza C. TassoneShakila ThangaratinamMala ThondanChii‐Ruey TzengZephne M. van der SpuyEszter VankyMaria G. VogiatziChing Shan WanChandrika WijeyaratneSelma F. WitchelJane WoolcockBülent Okan Yıldız

Abstract

The guideline was primarily funded by the Australian National Health and Medical Research Council of Australia (NHMRC) supported by a partnership with ESHRE and the American Society for Reproductive Medicine. Guideline development group members did not receive payment. Travel expenses were covered by the sponsoring organizations. Disclosures of conflicts of interest were declared at the outset and updated throughout the guideline process, aligned with NHMRC guideline processes. Full details of conflicts declared across the guideline development groups are available at https://www.monash.edu/medicine/sphpm/mchri/pcos/guideline in the Register of disclosures of interest. Of named authors, Dr Costello has declared shares in Virtus Health and past sponsorship from Merck Serono for conference presentations. Prof. Laven declared grants from Ferring, Euroscreen and personal fees from Ferring, Euroscreen, Danone and Titus Healthcare. Prof. Norman has declared a minor shareholder interest in an IVF unit. The remaining authors have no conflicts of interest to declare. The guideline was peer reviewed by special interest groups across our partner and collaborating societies and consumer organizations, was independently assessed against AGREE-II criteria, and underwent methodological review. This guideline was approved by all members of the guideline development groups and was submitted for final approval by the NHMRC.

Ovarian function and disordersReproductive Biology and FertilityOvarian cancer diagnosis and treatmentPolycystic ovaryGuidelineMedicineGynecologyOvaryInternal medicinePathologyInsulin resistanceInsulin

MeSH terms

FemaleHumansInfertility, FemalePolycystic Ovary SyndromePregnancyPractice Guidelines as TopicEvidence-Based Medicine

Funding

  • American Society for Reproductive Medicine
  • Children's Hospital of Philadelphia
  • University of Pennsylvania
  • Danone
  • Helsingin Yliopisto
  • University of Pittsburgh
  • University of Rochester
  • Pennsylvania State University
  • Norges Teknisk-Naturvitenskapelige Universitet
  • Queen Mary University of London
  • Université de Lille
  • Sanjay Gandhi Postgraduate Institute of Medical Sciences
  • Imperial College London
  • Australian Catholic University
  • Deakin University
  • Monash University
  • Victoria University
  • University of Adelaide
  • University of Hong Kong
  • Karolinska Institutet
  • Taipei Medical University
  • Universidade Federal do Rio Grande do Sul
  • Hacettepe Üniversitesi
  • Universidad de Chile
  • University of Cape Town
  • Peking University
  • Peking University Third Hospital
  • University of Colombo
  • European Society of Human Reproduction and Embryology
  • Penn State College of Medicine
  • Medical Research Council
  • National Health and Medical Research Council
  • Bhabha Atomic Research Centre
  • Taipei Medical University Hospital
  • Children's Hospital of Pittsburgh
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