Role of antiphospholipid antibodies in recurrent pregnancy loss

Abstract

Antiphospholipid syndrome is associated with a hallmark of Obstetric complications including recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. These factors lead to a hypercoagable state leading to various obstetric complications. The aim of this study was to evaluate the prevalence of anti-phospholipid antibodies in patients with RPL and to evaluate the relation of antibody positivity with other parameters.