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Placental Pathology in COVID-19
American Journal of Clinical Pathology · 2020 · Vol. 154(1) · pp. 23–32
Elisheva D. Shanes(Northwestern University)Leena B. Mithal(Northwestern University)Sebastián Otero(Northwestern University)Hooman Azad(Northwestern University)Emily S. Miller(Northwestern University)Jeffrey A. Goldstein✉(Northwestern University)
Abstract
Relative to controls, COVID-19 placentas show increased prevalence of decidual arteriopathy and other features of MVM, a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. Only 1 COVID-19 patient was hypertensive despite the association of MVM with hypertensive disorders and preeclampsia. These changes may reflect a systemic inflammatory or hypercoagulable state influencing placental physiology.
COVID-19 Impact on ReproductionCOVID-19 and healthcare impactsMaternal and fetal healthcareCoronavirus disease 2019 (COVID-19)MedicinePathology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PandemicCoronavirus InfectionsBetacoronavirusVirologyOutbreak
MeSH terms
BetacoronavirusCOVID-19SARS-CoV-2AdultFemaleHumansPlacentaPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy Trimester, ThirdCase-Control StudiesCoronavirus InfectionsPandemics
Funding
- National Institutes of Health
Citations
626
FWCI
51.27
field-weighted impact
References
50
Percentile
100%
vs. same field & year
Citations per year
Cited by
Placental Pathology in COVID-19
American Journal of Clinical Pathology · 2020 · 409 citations
Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis
American Journal of Obstetrics and Gynecology · 2020 · 662 citations
References
Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis
American Journal of Roentgenology · 2020 · 592 citations
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study
Intensive Care Medicine · 2020 · 2,889 citations
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