Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-COV-2: Case series

Abstract

COVID-19 associated MIS-C like the disease has not been well described in neonates. So this study aimed to alert the neonatal community to the possibility of the multisystem inflammatory syndrome in children (MIS-C) like disease in critically ill neonates born to mothers with or without a history of SARS-CoV-2 infection or exposure. It’s a retrospective study of four neonatal cases admitted in Dr. DY Patil Medical College NICU. All four cases are from different localities with sharing of common antepartum, intrapartum and postpartum period. All are preterm with meconium aspiration syndrome. All are presented on day three of life with dark red color vomiting and respiratory distress. All Babies were normal initial three days. Early treatment with IVIG and surfactant were showed rapid clinical improvement in all four cases. SARS-CoV-2 associated MIS-C like the disease has not been well described in neonates. Even though WHO defined criteria for MIS-N, that typical features may be conspicuously absent. Therefore a high index of suspicion is warranted in critically ill neonates who presented after a period of normality about three days with the above symptoms.