Correlation of clinical features with positive autologous serum skin test in Urticaria

Abstract

Autologous serum skin test (ASST) is the simplest and the best in vivo clinical test for the detection of basophil histamine- releasing activity. In India, ASST positivity was found to be 26.67% in chronic Urticaria. The details enquired from the patients include duration of disease, duration of individual wheals, frequency of attacks, distribution of wheals, associated systemic symptoms, provoking physical factors, food and drug intolerance, seasonal variation, associated angioedema. Out of total 60 patients, 38 patients gave history of exacerbation of symptoms during evening time. But there was no statistical correlation with ASST positivity. Out of total 60 patients 25 patients were found to have increased serum IgE values, of which 17 (68%) were ASST positive, found to be statistically significant.