Maternal vitamin D levels in patients with hypertensive disorders of pregnancy

Abstract

Objective: To evaluate maternal vitamin d levels in patients with hypertensive disorders of pregnancy.Material and Method: The present case-control study was conducted among 150 pregnant women attending gynaecological OPD during July 2019-January 2020. On admission, patient demographic profile, complete history was recorded, and comprehensive clinical examination was done. In all the patients, blood samples for routine examination along with LFT, RFT, random blood sugar, serum electrolytes, serum uric acid and serum vitamin D were drawn, and serum levels of these biochemical parameters were determined according to standard laboratory procedures. Subjects were classified into four categories according to serum vitamin D level i.e. >20ng/ml (suboptimal to optimal), 10-20 ng/ml (mild deficiency), 5-10ng/ml (severe deficiency) and <5 ng/ml (very severe deficiency).Results: Insignificant difference was found between case (hypertensive) and control (normotensive) group when compared in relation to age, education and socioeconomic status. Vitamin D<5 and >20ng/ml was revealed among 20%, 5.33% and 6.67%, 14.67% of the subjects in case and control group respectively. Mean vitamin level was 9.16±4.93 and 13.94±6.17 ng/ml in case and control group respectively with statistically significant difference as p<0.05. Mean serum calcium was found comparatively higher among control group (8.84±1.11) as compared to case group (8.21±1.34). Conclusion: The results of the present study concluded that women with hypertension had significantly lower vitamin D level as compared to normotensive women.