Role of priming principle in the induction dose requirement of propofol and hemodynamic stability

Abstract

Aim: To study the role of priming principle in the induction dose requirement of propofol and hemodynamic stability. Methods: This observational study conducted in the, Department of Anaesthesia. 80 patients of age between 20-57 years, come under ASA-I or ASA-II category undergoing surgery which requires general anaesthesia as a mode of anaesthesia chosen to determine effect of priming principle in relation to Propofol. Results: The mean induction dose in group A was 81.22±9.68 and in group B it was 113.02±12.63. Thus we observed a 25% reduction in induction dose requirement in group A. The rise in Pulse rate was highly significant at one minute after induction, during intubation, immediately after intubation & 5 minutes later. Two groups were comparable to each other with respect to age, weight, ASA physical status. There was no significant difference in baseline pulse rate & baseline SBP, DBP & MAP, oxygen saturation between group A & Group B (p value > 0.05). Conclusion: Based on the results from this study it is concluded that application of priming principle to the induction dose of propofol will reduce the total induction dose of propofol.