Acute and subacute toxicity of Solanum aethiopicum Linn Gilo (Solanaceae) aqueous leaves extract in Wistar rats

Abstract

The aims of this study was to evaluate the acute and sub-acute toxicity of Solanum aethiopicum Linn Gilo aqueous leaves extract in Wistar rats. Female rats received a single dose (2000, 3000, 4000 and 5000 mg/kg/ bw) of the extract for acute toxicity. Both, male and female rats received 300,500 and 800 mg/kg/ bw during 21 days for sub-acute toxicity measurements. Blood sample was collected for the determination of some haematological, biochemical and oxidative stress parameters. Besides, the histological sections of the liver, heart, lungs and kidneys were analyzed. Results showed that the lethal dose of the extract greater than 5000mg/kg. the extract did not alter the haematological parameters. It maintained blood sugar and proteinuria within normal limits and had good antioxidant activity. The histopathological analysis revealed normal architecture of lung, kidney, heart and liver. Solanum aethiopicum LINN GILO aqueous leaves extract at doses of 300,500,800mg/kg/bw has therefore shown any sign of toxicity.