Prospective case-control hospital based study to clinically evaluate the levels of high-sensitivity C-reactive protein in patients with type 2 diabetes

Abstract

Aim: To determine the high-sensitivity C-reactive protein levels in patients with type 2 diabetes mellitus.Methods: This prospective observational study was carried out at Dhawan Hospital, Ludhiana, Punjab, India, from April 2021 to November 2021. The study was undertaken on 40 type 2 Diabetes mellitus and 40 normal healthy controls. All the patients were advised to fast overnight. Blood samples were collected in fasting condition. 5ml venous blood was collected from the each subject and it was transferred to the Plain tube and serum is separated by centrifugation and stored at -200C for measured. Estimation of Plasma Glucose by the Glucose Oxidase and Peroxidase (GOD POD) method and estimation of hs-CRP by turbidometric immunoassay using commercially available kit Results: Fasting blood glucose, post prandial blood glucose, and hs-CRP levels was measured in 80 T2DM cases and 80 age and gender matched healthy controls. The mean and standard deviation were calculated for all the Biochemical parameters. The significance between the groups was determined using Student t- test for Equality of means. The p-value of < 0.05 was considered significant.Conclusion: From this study it is observed that there is moderate correlation between hs-CRP levels and it increases the risk of atherosclerosis.