A comparative study between ramosetron and palonosetron in preventing postoperative nausea and vomiting in laparoscopic surgeries

Abstract

Objective: To study the efficacy and side effects of single dose of ramosetron and palonosetron i.v. for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries. Methods: 60 patients of JSS hospital, Mysore posted for elective laparoscopic surgeries in the age group 18- 55 yrs of either sex & physical status ASA I and ASA II were included in the study. Group I (n= 30) received (0.075mg) palonosteron i.v. Group II (n= 30) received (0.3 mg) ramosetron i.v. Results: The age and sex distribution of both the groups were similar. There was a significant reduction in the incidence of nausea and vomiting in palonosetron group compared to ramosetron, need for rescue antiemetic, side effects were less in palonosetron group, when compared to ramosetron. Conclusion: In our study, we observed that the incidence of nausea and vomiting was low with palonosetron when compared with ramosetron, but statistically not significant.