A study to compare the attenuation of haemodyanamic stress response during intubation by fentanyl, Nalbuphine and butorphanol

Abstract

Several techniques have been tried in an effort to attenuate adverse hemodynamic stress responses to intubation. Commonly used techniques include increasing the depth of anesthesia by heavy premedication, inhalational anesthetic agents, intravenous (IV) and topical lignocaine, clonidine and dexmedotomidine, calcium channel blockers, sodium nitroprusside, beta-adrenergic blockers, and magnesium sulfate. Ninety female patients of 18-65 years of age, undergoing elective modified radical mastectomy (MRM) surgery for carcinoma breast at Kidwai Memorial Institute of Oncology, Bangalore were selected randomly. The study was conducted in the Department of Anesthesia and pain relief, Kidwai Memorial Institute of Oncology, Bangalore during the period from December 2018 to December 2019. So, in terms of Heart rate control during intubation and steady state of anaesthesia all three opioids showed efficacious control but Nalbuphine proved to be best as it prevented tachycardia during intubation.