Comparative assessment of oxidative stress in dogs regarding CPV infection

Abstract

Oxidative stress plays crucial role in the pathogenesis of many disease conditions including CPV infection. This study was planned to compare oxidative stress level in CPV infected and non CPV infected dogs which included a total of thirty six dogs which were diagnosed with molecular technique like polymerase chain reaction for the detection of CPV in faecal samples. Oxidative stress estimation was done by measurement of antioxidant enzymes like superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) and trace elements like copper, iron and zinc. So, these dogs were further targeted with combined antibiotic and antioxidants therapy to combat oxidative stress. CPV positive dogs showed higher oxidative stress than CPV negative dogs and also showed early clinical recovery because of antioxidant therapy. These findings helped in demonstrating the significance of antioxidants in treatment protocol.