Clinical, pathological and immunohistochemical bovine papillomatosis

Abstract

The present clinical study was conducted to study incidence, clinical symptoms, histopathological and immunohistochemical findings of bovine papillomatosis. Among total of 3812 cattle presented to the clinic, 52 cattle were having papillomas. No incidence of papillomas was recorded in buffaloes. Highest incidence of bovine papillomas was observed in cattle of 3 years age. Jersey crossbred cows were the most commonly affected breed followed by HF cross breed and non – descript cows. Most of the papillomas were located on teats only (40.38%) followed by teats and udder (21.15%). Histopathologically, fibro papilloma (60%) was found to be most common papilloma followed by Angio keratotic acanthomatous papilloma (40%). Immunohistochemical studies were conducted to know the rate of proliferation of bovine papillomas. Immunopositive reaction was observed against VEGF in Angio keratotic acanthomatous papilloma. EGFR and Ki67 immunopositivity was observed in fibropapillomas.