The level of maternal serum galectin-1 and galectin -3 levels in pregnancies complicated with preterm prelabour rupture of membrane

Abstract

Background: Rupture of membranes occurring prior to 37 weeks of gestation. It complicates Approximately 2% of pregnancies, and 40% of these cases result in preterm delivery, contributing significantly to increased neonatal morbidity and mortality. Objective: To assess the level of maternal serum galectin-1 and galectin -3 levels in pregnancies complicated with preterm prelabour rupture of membrane. Patients and method: A case control study that carried out in Obstetrics and Gynecology Department at Baghdad Teaching hospital from the first of Jan 2020 to the end of Dec 2020. A sample of 200 pregnant women participated in the study within gestational age (24 -<36+6) weeks. Results: The level of Galectin-1 was (11763±389) in PROM group and (11443±599) for normal group with highly significant increase in case group than that in normal group (P< 0.001). Galectin-3 was (3112±329) in PROM group and (2711±265) for normal group with highly significant increase in case group than that in normal group (P< 0.001). The validity test of the Galectin-1 to detect the PROM at cutoff value≥11721 and AUC= 0.93 was; Sensitivity (94%), specificity (78%), NPV (90%), PPV (80%) and accuracy was (88%), and the validity test of the Galectin-3 to detect the PROM at cutoff value ≥2990 and AUC= 0.88 was; Sensitivity (89%), specificity (74%), NPV (86%), PPV (76%) and accuracy was (82%). Conclusion: Significant increase of Galectin-1 and 3 in Premature rupture of membrane than that in normal group (P< 0.001).