Association of clinicopathologic features with metastasis in clear cell renal cell carcinoma

Abstract

Objective: Metastasis is the most important prognostic indicator for clear cell renal cell carcinoma patients. The higher incidence of metastasis the higher incidence of death rate. To decrease death rate, understanding clinicopathologic features associated with clear cell renal cell carcinoma metastasis is required. Materials and Methods: Cross-sectional study was conducted to 40 cases of clear cell renal cell carcinoma in the Anatomical Pathology Department of Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital. To examine association between metastasis and clinicopathological features data were analyzed used Chi-Square test. P value ≤0.05 was considered significant. Results: Coagulative necrosis have associations with metastasis in clear cell renal cell carcinoma with significant result (p=008) Conclusions: Coagulative necrosis was associated with metastasis in clear cell renal cell carcinoma and may show the sign of tumor cell aggressiveness during metastasis process.