A study on pharmacokinetic parameters of glimepiride in experimental diabetes mellitus induced rats

Abstract

An experimental study was conducted to evaluate the interaction of Gymnema sylvestre extract with insulin and glimepiride in diabetic Sprague dawley rats. Rats were randomly divided into seven groups of six rats each. In this experiment pharmacokinetic interaction of glimepiride with Gymnema sylvestre extract was assessed. The pharmaco kinetic study revealed the values of half-life, Absorption rate constant, Elimination rate constant and time to achieve maximum concentration of glimepiride were significantly varied in Gymnema sylvestre pre-treated rats compared to normal rats administered with glimepiride.