Synthesis and spectroscopic characterization of Ni(II) and Cu(II) Schiff base Transition Metal Complexes from a mix of drugs Sulfamethaxole with 2-aminopyridine and Benzaldehyde

Abstract

The Schiff base ligands were synthesized by condensation reaction of 2-Aminopyridine and Benzaldehyde. The mixed ligand Complexes were synthesized by reaction of Schiff base with Metals (II) salt and Sulfamethoxazole drug in a ratio of 1:1:1 {M: (L1): (L2)}. The metal(II) complexes were formed by refluxing the chloride salts of the metals with the Schiff base ligand. The Schiff base and its complexes were characterized by melting point/decomposition temperature, solubility test, molar conductance measurement, infrared and UV-visible spectral analysis. The ligand and the complexes were coloured, non-hygroscopic and air stable. The conductivity measurement data revealed that the complexes are non-electrolytes. The infrared data indicated the bidentate nature of the Schiff base ligand coordinated with the metal ions via the nitrogen atom of the azomethine(C=N) and oxygen atom of the hydroxyl group after deprotonation.