Ropivacaine and bupivacaine for supraclavicular brachial plexus: Hemodynamic changes

Abstract

The CNS effects occurred earlier than cardiotoxic symptoms during an intravenous infusion of local anesthetic (10 mg/min of ropivacaine or bupivacaine) in human volunteers and the infusion was stopped at this point. Significant changes in cardiac function involving the contractility, conduction time QRS width occurred and the increase in a QRS width was found to be significantly smaller with ropivacaine than with bupivacaine. Informed and written consent was taken from selected patients. Following approval of institutional ethics committee, 60 patients aged 20-60 years, weighing more than 50 kgs were taken up for the study. All the patients were evaluated thoroughly on the previous day of the surgery. A detailed history, complete physical examination and routine investigations were done for all patients were explained about procedure. Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) between two groups are comparable and statistically not significant. There were no variations in blood pressure between two group. Both the groups had good hemodynamic control throughout the study and did not show a significant difference at any time interval.