A study to observe the effectiveness of administration of intrathecal midazolam as an adjunctive to spinal anesthesia

Abstract

Aim: The present study was undertaken to observe the efficacy of midazolam as an adjunctive to spinal anesthesia. Materials and Methods: The study recruited 40 patients with ASA grade 1 and 2, within the age group of 30-60 years. Patients of either sex were recruited in the study. After recruiting the participants, they were randomly divided into two groups. Group 1: (n=15): Control group – received 2.5 ml of 0.5% heavy bupivacaine plus 0.4 ml of 0.9% saline. Group 2: (n=15): Intervention group: received 2.5 ml of 0.5% heavy bupivacaine plus 0.4 ml (2 mg) of preservative free midazolam. All participants underwent thorough physical examination. Demographic data was recorded from the patients. To assess the efficacy, patients stress levels and pain scores were recorded using standard methods in the literature. Results: Table no 1 presents demographic data of the patients. Majority of the patients belongs to age group of 30-40 years. Table no 2 presents gender-based distribution of participants. Majority of participants were females. Table no 3 presents the STAI and VAS scores. There is a significant less anxiety scores in the group 2 when compared with group 1. VAS scores are significantly less in group 2 when compared with group 1. Conclusion: The study results support that midazolam is an effective adjunctive with spinal anesthesia. There is a need for further multi center and detailed studies in this area to support adoption of midazolam as an adjunctive with spinal anesthesia.