Histomorphologic analysis of non-neoplastic lesions in nephrectomy specimens

Abstract

Background and Objectives: Kidneys can be involved in various pathological processes, some of which require its surgical removal- Nephrectomy. A detailed histopathological analysis of renal lesions is mandatory for proper diagnosis. The present study aimed to analyze the histomorphological spectrum of non-neoplastic lesions in nephrectomy specimens received in our institution. Materials and Methods: A total of 80 nephrectomy specimens removed for non-neoplastic lesions were analyzed and a descriptive analysis was done. Results: We observed a male predominance in our study with a sex ratio of 1.16:1. Most cases affected were among the third decade with a mean age of presentation of 38.4 years. Maximum cases were pyelonephritis (PN) (86.4%), among which chronic pyelonephritis (CPN) with hydronephrosis (HDN) (23.8%) predominated, followed by infective, traumatic, cystic and developmental lesions. Conclusion: Wide diversity and overlapping features in renal diseases calls for a thorough evaluation of morphological parameters, for planning therapy and predicting disease outcome.