Designer nanomaterials for cancer management and therapy: Recent advances and challenges

Abstract

Nanotechnology has the potential to overcome several disadvantages of traditional therapeutic formulations. Nanotechnology has been extensively researched and used in cancer treatment because nanoparticles can play a significant role as a drug delivery system. Nanoparticle-based drug delivery has several advantages, including improved stability and biocompatibility, increased permeability and retention, and precise targeting. Furthermore, by modifying their composition, size, morphology, and surface chemistry, nanomaterials can be designed for increased drug loading, controlled release, and selective distribution. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. As a result, in this review, we summarise a variety of nanomaterials currently used in anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We also talk about nanotoxicity, which is an often-overlooked aspect of nanotechnology. Finally, we summarise the current challenges in nanotherapeutics and provide an outlook on the future of this important field.