The comparative efficacy of prophylactic parenteral antibiotics with combined parenteral and pre-operative intra-incisional antibiotic administration in reducing surgical site infection

Abstract

It has been proven to provide systemic cover by the absorption of the antibiotic from the incision site. This is primarily because the antibiotic gets fixed to the tissues along the incision and thus the antibiotic is present in a high concentration during time of maximum contamination of incision. Patient and/or his/her legally acceptable representative were explained about the study in detail and after obtaining their verbal consent for participation written voluntary informed consent was obtained. After obtaining the written consent the study related procedure was initiated. In Group 1, SSI was present in 7 (11.7%) patients and in Group 2 it was present in 1 (1.7%) patient. There was a significantly higher number of patients of SSI in group 1 in comparison to the Group 2 (P>0.05). In Group 1, 2 (3.33%) patients required resuturing, while in Group 2 none of the patients required any resuturing. There was statistically no significant difference in need for resuturing in both the groups (P>0.05).