A Clinico pathological study on Pemphigus vulgaris with cytological and histopathological correlation and with possible confirmation with immunofluorescence

Abstract

Pemphigus vulgaris (PV) is a potentially fatal, chronic autoimmune, vesiculobullous intraepithelial disease characterized by flaccid blisters and erosions of the skin and mucous membranes and histologically by acantholysis. It is mediated by circulating desmoglein-reactive autoantibodies directed against keratinocyte cell surfaces. Pemphigus vulgaris commonly occur in middle aged and elderly between the ages 40 to 60 years and effects men and women equally. Pemphigus vegetans is a clinical variant involves the large skin folds with vegetating lesions. Oral lesions are relatively non-specific and is difficult to diagnose. With early accurate diagnosis with cytological diagnosis, histopathological correlation and confirmation by using immunofluorescence techniques disease treatment, prognosis and outcome will be better.