Comparative study of acute oral toxicity of essential oils of Ocimum gratissimum, Hyptis suaveolens and Psidium guajava in wistar rats

Abstract

The essential oils from Ocimum gratissimum, Hyptis suaveolens (Lamiceae) and Psidium guajava (Myrtaceae) have biological properties. The aim of this work is to compare the effect of essential oils of these three medicinal plants on weight growth, hematological and biochemical parameters of treated rats through the procedure of acute toxicity evaluation on Wistar rats. The doses applied are 100, 250 and 500mg/Kg bw for each of the essential oils From the results obtained, the effects of essential oils of Ocimum gratissimum, Hyptis suaveolens and Psidium guajava leaves on biochemical, hematological parameters and weight growth of rats are dose dependent. At the dose of 500mg/Kg bw, they significantly increased the rate of white blood cells, urea, creatinemia, transaminases and reduced the weight growth of rats by more than 10% (p