Levothyroxine replacement in subclinical hypothyroidism during pregnancy and its effect on fetomaternal outcome

Abstract

Background: We aimed to study improvement in feto-maternal outcome in pregnant women with subclinical hypothyroidism treated with levothyroxine therapy. Methodology: This was prospective comparative study, on antenatal Women who had first trimester thyroid function tests at our Hospital. All female were categorized into three groups (Group A- TSH level>2.5-4 μIU/l receiving levothyroxine treatment; group B- TSH level between 4.1-10 μIU/l receiving levothyroxine treatment and Group C- women with TSH level >2.5-4 μIU/l not receiving levothyroxine treatment). Fetomaternal outcome was assessed between the groups. Results: We observed no significant difference in maternal outcome between three groups but APGAR score was significantly lower in group B as compared to other two groups (p<0.05). Conclusion: Levothyroxine replacement therapy is safe and effective in case of subclinical and overt hypothyroidism & in SCH pregnancy loss in mother & neonatal admission rate to NICU shows a significant decrease on levothyroxine administration.