article Open Access
C-H-Activation approach in the synthesis of palonosetron core: A 5-HT3 receptor antagonist
The Pharma Innovation · 2021 · Vol. 10(4) · pp. 22–25
Vivek Mishra✉(University of Tübingen)Martin E. Maier(University of Tübingen)
Abstract
Intramolecular rhodium (III) catalyzed annulation of benzamide 8 has been described in the efficient synthesis of palonosetron core, 5-HT3 receptor antagonists. C–H-activation enabled the simultaneous generation of rings B and C, which can further be functionalized to access a series alkaloid.
Catalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisOrganic and Inorganic Chemical ReactionsPalonosetronBenzamideChemistryAntagonistAnnulationStereochemistryIntramolecular forceReceptorCatalysisAnesthesia
Funding
- Deutscher Akademischer Austauschdienst
- Eberhard Karls Universität Tübingen
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