A walk around A 3 Coupling for the synthesis of Propargylamines

Abstract

Propargylamines are a versatile class of compounds which find broad application in many fields of chemistry. This review aims to describe the different strategies developed so far for the synthesis of propargylamines and their derivatives as well as to highlight their reactivity and use as building blocks in the synthesis of chemically relevant organic compounds. In this review, the different synthetic approaches to synthesize propargylamines using different metal and metal ion immobilized ionic liquids and metal catalyst free such as A3 couplings and C–H functionalization of alkynes, have been described and organized on the basis of the catalysts employed in the syntheses. A metal-free and straightforward greener protocol for the preparation of propargylamine has been reported.