The role of reactive oxygen species (ROS) in osteoarthritis patients

Abstract

Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic processes. The generation of ROS can also provoke damage to multiple cellular organelles and processes, which can ultimately disrupt normal physiology. Reactive oxygen species (ROS) are produced mainly during oxidative phosphorylation and by activated phagocytic cells during oxidative burst. The excessive production of ROS can damage lipids, protein, membrane and nucleic acids that may contribute to the development of oxidative stress mediated diseases. In this study, healthy controls and osteoarthritis patients were evaluated for the oxidant-antioxidant status by measuring ROS production.