Evaluation of the anti-diabetic activity of ethanol extract of leaves of Scurrula parasitica in streptozotocin-induced diabetic rats

Abstract

The current study investigated antihyperglycemic, hypolipidemic, GCMS analysis of ethanolic leaf extract of Scurrula parasitica. A total of 30 albino rats (5 groups, each having 6 rats) weighing around 150 to 200gm were selected injected with streptozotocin to increase the glucose level. After the induction of diabetes, rise in blood glucose level and elevation of biochemical parameters such as High-density lipoprotein (HDL), Low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), Total Cholesterol (TC), Triglyceride (TG), SGOT, SGPT, Alkaline phosphate and lowering of HDL was observed. The rats were treated with ethanol extract of Scurrula parasitica and compared with metformin, which is used as standard drug. The plant extract was given at 100 and 200mg/kg body weight. After administration with the plant extracts, significant lowering of blood glucose level and lipid serums with rise of HDL serum cholesterol was observed when compared to the diabetic control group after the 21st day. 5 anti-diabetic compounds were identified in the GC-MS analysis of the ethanolic extract of the leaves of Scurrula parasitica. This research illustrates that the parasitic plant Scurrula parasitica has antihyperglycemic and hypolopidemic properties and can further be subjected to drug formulation to isolate a compound, which can be used for the treatment of diabetes.