Aspartate aminotransferase platelet ratio index (APRI) and fibroscan in predicting early fibrosis in non-alcoholic fatty liver diseases cases

Abstract

Nonalcoholic fatty liver disease (NAFLD) is emerging as an important cause of chronic liver disease in worldwide. Liver biopsy is a gold standard procedure in the diagnosis and staging of NAFLD, but there are several non-invasive diagnostic procedures have been emerged for the early diagnosis of liver fibrosis. The present study was designed to assess the efficacy of APRI to fibroscan as a marker for early fibrosis in cases with non-alcoholic fatty liver diseases. A total of 120 cases, which are newly diagnosed with non-alcoholic fatty liver disease attending OPD were recruited. Laboratory investigation results were obtained after overnight for evaluation of complete blood count, blood glucose levels, albumin, total bilirubin, platelet count, prothrombin time international normalized ratio, cholesterol, triglyceride (TG), serum urea, creatinine, HBsAg, HCV. Radiological evaluation was conducted by USG abdomen and fibroscan. The value of triglyceride was below 150mg/dl in 34.16% cases, between 150-200mg/dl in 45.83% cases and >200mg/dl in 20% cases. The fasting blood sugar was >100 in 40% cases and 0.7 would avoid the need for fibroscan.