To compare the clinical efficacy of dinoprostone slow release vaginal pessary and dinoprostone immediate release intracervical gel for induction of labor

Abstract

Background & Method: The present study was conducted in Department of Obstetrics and Gynaecology, Choithram Hospital & Research Centre, Indore (M.P.) from April 2019 to November 2019. After excluding all contraindications for normal labor, patients admitted in the labor ward of Choithram hospital, were divided in 2 groups of 30 women each. Antenatal profile was done in both the groups. Procedure was explained to patient and written informed consent was taken from all patients and the divided groups were induced accordingly. Result: In Dinoprostone Gel group the incidence of diarrhea was 10.0%, while in the Dinoprostone Pessary group it was 6.7%. The proportional comparison between the two groups was found to be not significant (p=0.64). In Dinoprostone Gel group the incidence of hyper stimulation was 3.3%, while in the Dinoprostone Pessary group it was 6.7%. The proportional comparison between the two groups was found to be not significant (p=0.552). In Dinoprostone Gel group the incidence of PPH was 13.3%, while in the Dinoprostone Pessary group it was 10.0%. The proportional comparison between the two groups was found to be not significant (p=0.687). In Dinoprostone Gel group the incidence of shivering was 6.7%, while in the Dinoprostone Pessary group it was 6.7%. The proportional comparison between the two groups was found to be not significant (p=1.000). In Dinoprostone Gel group the incidence of vomiting was 0.0%, while in the Dinoprostone Pessary group it was 3.3%. The proportional comparison between the two groups was found to be not significant (p=0.309). The incidence of maternal complications was comparable between the two groups. Conclusion: Dinoprostone preparations, gel and intravaginal pessary are safe and effective for cervical ripening and induction of labor. Induction delivery interval, requirement of Oxytocin augmentation is less in pessary group when compared to gel group. The dinoprostone slow release vaginal insert seems to be easy to use, effective and safe for the mother's and fetus's health.