Extra-pulmonary tuberculosis (EPTB): Study of clinico-demographic profile, and comparison of microbiological diagnostic modalities with special emphasis on role of CBNAAT in detecting rifampicin resistance in fluid specimens

Abstract

The purpose of our study was to evaluate the place of CBNAAT in the diagnosis of extra-pulmonary TB in fluid specimens, and also detecting drug resistance in comparison to the Gold Standard - MGIT Bactec Culture. Material and Methods: In prospective observational study of 2 yrs. among 165 EPTB cases, we studied the clinical presentation, compared the results of microbiological diagnostic modalities (ZN smear, CBNAAT, MGIT Culture) and evaluated the drug resistance. Statistics: Used Chi square test via software STATA 15 and calculated p value.Results: The positivity rate of CBNAAT (31.30%) was higher than ZN smear (23.92%), which was in turn higher than MGIT culture (9.9%) and CBNAAT was able to detect Rifampicin resistance in 16.66% EPTB cases. Conclusion: We concluded that, the role of CBNAAT in fluid specimens should not be undermined and should be preferred over the “Gold standard” MGIT culture.