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Acyl-coenzyme A:cholesterol acyltransferases
American Journal of Physiology-Endocrinology and Metabolism · 2009 · Vol. 297(1) · pp. E1–E9
Abstract
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated ReceptorsLipid metabolism and biosynthesisAcyltransferasesBiochemistryCoenzyme ACholesterolEnzymeSterol O-acyltransferaseAcyl-CoAIsozymeChemistryBiology
MeSH terms
Amino Acid SequenceAnimalsSterol O-AcyltransferaseHumansModels, BiologicalMolecular Sequence DataProtein ConformationLipid Metabolism
Funding
- Ministry of Science and Technology of the People's Republic of China
Citations
503
FWCI
21.79
field-weighted impact
References
105
Percentile
100%
vs. same field & year
Citations per year
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References
Coronary Plaque Disruption
Circulation · 1995 · 3,514 citations
Atherosclerosis — An Inflammatory Disease
New England Journal of Medicine · 1999 · 21,632 citations
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