Histomorphological spectrum of noninfectious vesiculobullous lesions of skin: A rural area based study

Abstract

Background: Vesiculobullous lesions are the major contribution of various skin disorders. They are primary morphological representation of various pathological stimuli. Histopathology plays major role in the initial phase of diagnosis helps in further evaluation to identify the underlying etiology. Aim and Objective: To study the prevalence of various morphological types of vesiculobullous skin lesions in different age groups in a rural area. Methodology: A Retrospective study conducted from May 2018 to May 2021, at Katuri Medical College & Hospital, Guntur. A study of vesiculobullous lesions of the skin biopsies of 90 cases was received to the department of pathology, at Katuri Medical College & Hospital, for 3 years. Complete clinical and relevant history was recorded. The specimens were routinely processed and H&E-stained slides were studied. Results: Out of 454 skin biopsies, of which 90 cases (19.8%) were diagnosed as vesiculobullous lesions by histopathologically. Pemphigous vulgaris comprised 38 cases (42.23%) followed by Bullous pemphigoid 24 cases (26.67%), in clinically suspected Autoimmune Bullous Disorders. Conclusion: Clinical examination has greater significance in diagnosis still histopathological examination plays vital role, helps to arrive at a definitive diagnosis in the majority of vesiculobullous disorders. Skin biopsy is inexpensive, carried out as OPD procedure with minimal discomfort to the patient.